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Induction of hyperthermia using implanted electrodes.

O H Frazier, P M Corry

    Cancer Research
    |October 1, 1984
    PubMed
    Summary
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    Interstitial hyperthermia offers reliable, low-toxicity local tumor control, achieving significant therapeutic temperatures. Its main limitation is the need for surgical electrode placement, restricting use to patients undergoing tumor resection.

    Area of Science:

    • Oncology
    • Medical Physics
    • Surgical Oncology

    Background:

    • Interstitial hyperthermia has been utilized since 1978 for local tumor control.
    • This technique is indicated when local control is clinically important and achievable.

    Purpose of the Study:

    • To evaluate the initial experience and efficacy of interstitial hyperthermia.
    • To determine the feasibility and limitations of this local hyperthermia method.

    Main Methods:

    • Eleven patients undergoing exploration for primary or metastatic lesions were treated.
    • Hyperthermia treatments lasted 1 hour, with 5 to 25 sessions per patient.
    • Target tumor temperatures of 50°C were aimed for, with average temperatures over 43°C achieved.

    Main Results:

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    • Interstitial hyperthermia proved to be a reliable and low-toxicity method for inducing local hyperthermia.
    • Therapeutic tumor temperatures were consistently achieved.
    • The primary limitation identified was the requirement for surgical exploration to implant electrodes.

    Conclusions:

    • Interstitial hyperthermia is an effective and safe modality for local tumor control.
    • Its application is currently limited to patients selected for surgical exploration and tumor extirpation.