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Related Experiment Videos

Multiple-dose ciprofloxacin kinetics in normal subjects.

G E Aronoff, C H Kenner, R S Sloan

    Clinical Pharmacology and Therapeutics
    |September 1, 1984
    PubMed
    Summary

    This study on ciprofloxacin pharmacokinetics found that while drug accumulation did not occur, its elimination half-life increased with multiple doses. These findings support further clinical trials for systemic infections.

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    Area of Science:

    • Pharmacology
    • Clinical Pharmacy
    • Drug Metabolism

    Background:

    • Ciprofloxacin is a quinoline carboxylic acid derivative antibiotic.
    • Understanding its multiple-dose pharmacokinetics is crucial for effective treatment.

    Purpose of the Study:

    • To determine the multiple-dose pharmacokinetics of ciprofloxacin.
    • To assess drug accumulation and changes in elimination parameters.

    Main Methods:

    • 12 healthy subjects received 250 mg oral ciprofloxacin every 12 hours for 13 doses.
    • Plasma concentrations were measured using High-Performance Liquid Chromatography (HPLC).
    • Peak and trough plasma concentrations were monitored daily.

    Main Results:

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  • Ciprofloxacin was rapidly absorbed, reaching peak serum concentrations around 1 hour post-dose.
  • Elimination half-life (t1/2) significantly increased from 3.71 hr (first dose) to 6.51 hr (thirteenth dose).
  • Apparent plasma clearance decreased, primarily due to reduced nonrenal clearance; no significant drug accumulation was observed.

    • Conclusions:

    • Achievable plasma concentrations exceed minimum inhibitory concentrations for many pathogens.
    • Further controlled clinical trials are warranted to evaluate ciprofloxacin efficacy in systemic infections.