Effect of intravenous tubing lumen diameter on drug delivery

The effect of intravenous (i.v.) tubing internal diameter and the position of the injection port on drug delivery were evaluated in an in vitro model. Two sets of i.v. tubing were compared and these were identical except for the diameter of the lumen. The large bone tubing took twice as long for the delivery of 95% of the drug compared to the small bore (120 and 60 min, respectively). In a separate study, identical (small bore) tubing was used to evaluate the effect of two injection port positions on drug delivery. The Y site injection port was placed with the injection hub pointing up or pointing down. Drug delivery times in these two specific positions were not statistically different.