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Related Experiment Videos

Fibrinogen turnover in progressive systemic sclerosis.

G M Gratwick, R Klein, J S Sergent

    Arthritis and Rheumatism
    |April 1, 1978
    PubMed
    Summary
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    Patients with scleroderma exhibit accelerated plasma fibrinogen turnover, indicating increased consumption. This finding suggests a potential link between fibrinogen metabolism and the vascular abnormalities observed in systemic sclerosis.

    Area of Science:

    • Nephrology
    • Rheumatology
    • Hematology

    Background:

    • Progressive systemic sclerosis (scleroderma) is associated with fibrin deposition in renal arterioles.
    • The relationship between fibrin deposition and plasma fibrinogen metabolism in scleroderma is not fully understood.

    Purpose of the Study:

    • To investigate whether plasma fibrinogen turnover is increased in patients with scleroderma.
    • To explore the potential correlation between fibrinogen turnover and disease progression in scleroderma.

    Main Methods:

    • Utilized 125I-labeled fibrinogen to measure plasma fibrinogen half-life in 15 scleroderma patients and normal controls.
    • Compared fibrinogen half-life between progressive and stable scleroderma subgroups.
    • Assessed the effect of intravenous heparin administration on fibrinogen half-life in a subset of patients.

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    Main Results:

    • Scleroderma patients demonstrated a significantly shorter plasma fibrinogen half-life (60.7 hours) compared to normal controls (90.6 hours).
    • Patients with progressive scleroderma exhibited a more rapid fibrinogen turnover (56.5 hours) than those with stable scleroderma (73.2 hours).
    • Intravenous heparin administration normalized fibrinogen half-life in treated patients, suggesting normal fibrinogen survival capability.

    Conclusions:

    • Plasma fibrinogen turnover is accelerated in scleroderma, likely due to increased consumption.
    • Fibrinogen turnover rate may serve as a biomarker for disease activity in systemic sclerosis.
    • Intermittent fibrinogen consumption might explain the variability in half-lives observed over time in scleroderma patients.