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Spontaneous malformations in JW-NIBS rabbits
Jikken Dobutsu. Experimental Animals
|April 1, 1984
Summary
This study reports on spontaneous anomalies in JW-NIBS rabbits, finding external anomalies in 0.57% of fetuses and visceral anomalies in 0.16%. Skeletal and rib anomalies were also noted.
Area of Science:
- Developmental Biology
- Teratology
- Animal Models
Background:
- Spontaneous anomalies in animal models are crucial for understanding developmental processes.
- Establishing baseline frequencies of congenital anomalies in laboratory rabbits is essential for research integrity.
Purpose of the Study:
- To document the frequency and types of spontaneous external, visceral, and skeletal anomalies in JW-NIBS rabbits.
- To provide baseline data for future studies utilizing this rabbit model.
Main Methods:
- Examination of 1217 live fetuses from 195 pregnant JW-NIBS rabbits.
- Detailed recording of external, abdominal visceral, head/thoracic visceral, and skeletal anomalies.
- Statistical analysis of anomaly frequencies.
Main Results:
- External anomalies observed in 0.57% of fetuses (e.g., craniofacial, gastroschisis, microcephaly).
- Abdominal visceral anomalies (gallbladder agenesis, ovarian hypoplasia) found in 0.16% of fetuses.
- Head/thoracic visceral anomalies (1.73%) and skeletal anomalies (0.69%) were also documented, with 4.03% exhibiting 13 ribs.
Conclusions:
- JW-NIBS rabbits exhibit a low frequency of spontaneous anomalies.
- The characterized anomaly profile provides valuable reference data for research using this model.
- Further investigation into the etiology of observed anomalies may be warranted.