Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Persistent inverse maternal effect on corticosterone production in vitro.

P R Wood, J G Shire

    Experientia
    |September 15, 1984
    PubMed
    Summary

    Maternal factors significantly influence offspring corticosterone production, impacting adult hormone levels. Genetic background also plays a role in adrenal steroid output.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Died of wounds: a mortality review.

    Journal of the Royal Army Medical Corps·2015
    Same author

    Anaesthesia at Role 4.

    Journal of the Royal Army Medical Corps·2011
    Same author

    Evolution of the role 4 U.K. military pain service.

    Journal of the Royal Army Medical Corps·2011
    Same author

    Dust formation in a galaxy with primitive abundances.

    Science (New York, N.Y.)·2009
    Same author

    Diagnosis of tuberculosis.

    Lancet (London, England)·2003
    Same author

    Antibody-dependent cell-mediated cytotoxicity to newly excysted juvenile Fasciola hepatica in vitro is mediated by reactive nitrogen intermediates.

    Parasite immunology·2001

    Area of Science:

    • Endocrinology
    • Genetics
    • Developmental Biology

    Background:

    • Adrenal steroidogenesis is crucial for physiological regulation.
    • Understanding genetic and maternal influences on hormone production is vital.

    Purpose of the Study:

    • To investigate the genetic and maternal effects on corticosterone production in mice.
    • To determine the interplay between genotype and maternal phenotype in adrenal steroidogenesis.

    Main Methods:

    • Comparative analysis of adrenal steroid production in different mouse strains (C57BL/Tb and DBA/2J).
    • Evaluation of reciprocal crosses (backcross and F1 hybrids) to assess maternal effects.
    • Measurement of corticosterone output in adult offspring.

    Main Results:

    • Adrenal cells from C57BL/Tb mice exhibited higher steroid production compared to DBA/2J mice.
    • A consistent maternal effect was observed in reciprocal crosses, indicating maternal influence.
    • High-output mothers produced offspring with reduced adult hormone production.

    Conclusions:

    • Corticosterone output is determined by both the maternal phenotype and the genotype of adrenal cells.
    • Maternal effects can override or modulate genetic predispositions in hormone production.
    • This study highlights the complex inheritance of endocrine traits.

    Related Experiment Videos