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[Analysis of urine in the child without renal disease and with fever]
Insights
Pediatric patients with extrarenal infections often show temporary urinary abnormalities, including proteinuria and other findings. These changes typically resolve quickly, with normal urine samples before discharge.
Area of Science:
- Pediatric Nephrology
- Infectious Diseases
- Clinical Chemistry
Background:
- Extrarenal infections in children can lead to various clinical manifestations.
- Urinary abnormalities are sometimes observed in febrile pediatric patients.
- Understanding these transient changes is crucial for accurate diagnosis and management.
Purpose of the Study:
- To investigate the prevalence and types of urinary abnormalities in pediatric patients with extrarenal infectious diseases.
- To correlate urinary findings with clinical parameters such as fever, age, and disease type.
- To analyze the duration and severity of observed urinary abnormalities.
Main Methods:
- Analysis of 79 urine samples from 24 pediatric patients (5 months to 13 years) with fever and extrarenal infections.
- Testing for urine proteins, glucose, ketones, and hemoglobin; urinalysis was performed.
- Urine protein electrophoresis was conducted on samples with elevated protein levels.
Main Results:
- 70% of patients and 39% of samples exhibited proteinuria (above 4 mg/hr/m2), with levels up to 52 mg/hr/m2.
- Albumin and alpha-globulins were commonly excreted; beta- and gamma-globulins were less frequent.
- Other abnormalities included ketonuria (37%), erythrocyturia (29%), hemoglobinuria (21%), glycosuria (16%), cylindruria (12%), and leukocyturia (8%).
Conclusions:
- Urinary abnormalities, particularly proteinuria, are common in febrile pediatric patients with extrarenal infections.
- No significant correlation was found between urinary findings and fever, age, or specific disease type.
- These abnormalities were generally mild and transient, resolving within 1-4 days with negative urine cultures before discharge.
Abstract:
The study comprised 24 patients with ages between 5 months and 13 years and fever from different extrarenal infectious diseases. Seventy-nine samples of urine were taken to determine proteins, glucose, ketone, hemoglobine and study of the urinary sediment. Electrophoresis of proteins was practiced to samples with higher content of them. Considering a normal rate of protein the figure above 4 mg/hr/m2, 70% of the patients and 39% of samples showed abnormality with figures up to 52 mg/hr/m2, or 1,259 mg/l. All of them excreted albumin and alphaglobulins; 15, betaglobulins and 4, gammaglobulins. No relationship was found between the amount or type of protein excreted and the degree of fever, age of the patient or type of disease. Thirty-seven per cent of the patients showed ketonuria, 29% erythrocyturia, 21% hemoglobinuria, 16% glycosuria, 12% cylindruria, and 8% leukocyturia. The duration of abnormalities lasted from 1 to 4 days and the magnitude was usually mild, having obtained in all of the cases, a normal sample of urine and a negative urine culture before discharge of the patient. Findings with other studies are compared and the pathogenesis of abnormalities is discussed.