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Optimal dose of oral omeprazole for maximal 24 hour decrease of intragastric acidity.

B K Sharma, R P Walt, R E Pounder

    Gut
    |September 1, 1984
    PubMed
    Summary
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    Omeprazole effectively reduces 24-hour intragastric acidity in duodenal ulcer patients. A daily dose of 30 mg omeprazole (a proton pump inhibitor) is optimal for maximal acid reduction.

    Area of Science:

    • Gastroenterology
    • Pharmacology

    Background:

    • Duodenal ulcers are common gastrointestinal conditions.
    • Effective management requires significant reduction in gastric acid production.

    Purpose of the Study:

    • To determine the optimal dose of oral omeprazole for reducing 24-hour intragastric acidity in duodenal ulcer patients.
    • To assess the duration of acid suppression and effects on gastrin levels.

    Main Methods:

    • 59 experiments were conducted on nine patients with duodenal ulcers.
    • Intragastric acidity was measured over 24 hours before, during, and after omeprazole treatment.
    • Fasting plasma gastrin levels were also monitored.

    Main Results:

    • Omeprazole doses of 10, 20, and 30 mg/day decreased acidity by 37%, 90%, and 97%, respectively.

    Related Experiment Videos

  • Higher doses (60 mg/day) or extended treatment (2 weeks) did not yield further significant acid reduction.
  • A 26% decrease in acidity persisted one week after treatment cessation, with full recovery by seven weeks.
  • Fasting plasma gastrin levels increased significantly during omeprazole treatment.

    • Conclusions:

    • Omeprazole 30 mg/day is the optimal dose for maximal 24-hour intragastric acidity reduction in duodenal ulcer patients.
    • The drug demonstrates a sustained effect on acid suppression even after treatment cessation.