Is pentagastrin-stimulated secretion mediated by histamine?
Gut
|September 1, 1984
Summary
Pentagastrin stimulates gastric acid and histamine release in duodenal ulcer patients. Cimetidine blocks acid but not histamine release, supporting histamine
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Histamine is a key mediator in gastric acid secretion.
- The role of histamine release in response to pentagastrin requires further elucidation.
Purpose of the Study:
- To investigate the relationship between pentagastrin-induced acid and histamine secretion.
- To determine the effect of cimetidine on pentagastrin-stimulated histamine release and gastric acid output.
Main Methods:
- Duodenal ulcer patients underwent a two-hour pentagastrin infusion test.
- A subset received a 200 mg bolus of cimetidine after one hour of pentagastrin.
- Gastric acid and histamine output, along with plasma histamine concentrations, were measured.
Main Results:
- Pentagastrin stimulated both gastric acid and histamine secretion, with similar patterns.
- Gastric acid output correlated significantly with histamine output during pentagastrin infusion.
- Cimetidine inhibited gastric acid secretion but did not alter gastric histamine output or plasma histamine levels.
Conclusions:
- Pentagastrin-induced gastric histamine release is not inhibited by cimetidine.
- Histamine release into the circulation was observed following cimetidine administration.
- These findings support histamine as a major stimulant of pentagastrin-induced gastric acid secretion.
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