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Related Experiment Videos

Studies on PIVKA VII.

G Mariani, M G Mazzucconi, S Solinas

    Haemostasis
    |January 1, 1984
    PubMed
    Summary
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    Researchers studied factor VII activity and antigen in patients on oral anticoagulants. A portion of factor VII antigen, identified as PIVKA VII, was not adsorbed by barium chloride due to reduced gamma-carboxyglutamic groups.

    Area of Science:

    • Hematology
    • Biochemistry
    • Clinical Chemistry

    Background:

    • Oral anticoagulant therapy requires monitoring of coagulation factors.
    • Factor VII is a key vitamin K-dependent coagulation factor.
    • Understanding factor VII behavior is crucial for managing anticoagulant treatment.

    Purpose of the Study:

    • To evaluate factor VII activity (VII:C) and antigen (VII:Ag) in subjects on oral anticoagulants.
    • To investigate the adsorption characteristics of factor VII by barium chloride.
    • To identify and characterize non-adsorbable factor VII antigen.

    Main Methods:

    • Assessed VII:C and VII:Ag levels in 30 subjects on stabilized oral anticoagulant treatment.
    • Treated plasma samples with 1 M barium chloride to assess adsorption.

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  • Investigated cold-promoted activation of factor VII and its effect on adsorption.

    • Main Results:

    • Average VII:C and VII:Ag levels were 8.7 and 30.7, respectively.
    • Barium chloride adsorbed all VII:C and a corresponding amount of VII:Ag.
    • A portion of VII:Ag was not adsorbed by barium chloride, identified as PIVKA VII, due to deficient gamma-carboxyglutamic groups.

    Conclusions:

    • A subset of subjects exhibited cold-promoted activation of factor VII.
    • The non-adsorbable VII:Ag fraction by barium chloride represents PIVKA VII.
    • This finding aids in understanding vitamin K-dependent protein carboxylation and anticoagulant effects.