Related Experiment Videos
A simple 18O water target for 18F production.
The International Journal of Applied Radiation and Isotopes
|July 1, 1984
Summary
A novel low-volume target efficiently produces Fluorine-18 (18F) for radiopharmaceutical synthesis. This simple copper target, plated with nickel, yields over a curie of 18F per run.
Area of Science:
- Nuclear Chemistry
- Radiopharmaceutical Science
Background:
- Production of Fluorine-18 (18F) is crucial for Positron Emission Tomography (PET) imaging.
- Existing methods for 18F production often require complex or large-volume targets.
Purpose of the Study:
- To develop a simple, low-volume target for efficient 18F production.
- To assess the yield and suitability of the produced 18F for radiopharmaceutical applications.
Main Methods:
- Construction of a 3 mL target using copper with a nickel-plated water cavity.
- Proton irradiation of oxygen-18 (18O) enriched water within the target.
Main Results:
- The target routinely produces over one curie of 18F.
- The produced 18F is in the form of [18F]fluoride, suitable for synthesis.
Conclusions:
- A simple, low-volume target design enables efficient production of high-activity 18F.
- This method is a viable option for routine 18F supply for radiopharmaceutical synthesis.