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A comparative study of infective endocarditis.

E Grossman, E Holtzman, T Rosenthal

    Israel Journal of Medical Sciences
    |May 1, 1984
    PubMed
    Summary
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    Infective endocarditis patterns shifted over two decades, with older patients and more heart disease. Rheumatic heart disease and Streptococcus viridans remained the most common factors, with no drug addiction cases observed.

    Area of Science:

    • Cardiology
    • Infectious Diseases
    • Epidemiology

    Background:

    • Infective endocarditis (IE) is a serious infection affecting heart valves.
    • Understanding temporal trends in IE is crucial for effective management.
    • Chaim Sheba Medical Center provides a valuable setting for long-term disease surveillance.

    Purpose of the Study:

    • To compare clinical features, microbiology, and therapy of infective endocarditis between two distinct decades.
    • To identify changes in patient demographics and underlying conditions over time.
    • To assess the impact of evolving medical practices on IE management.

    Main Methods:

    • Retrospective analysis of 213 patients (228 episodes) with infective endocarditis.
    • Data collected from two nonconsecutive decades: 1951-1960 and 1970-1979.

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  • Comparison of patient age, underlying heart disease, causative pathogens, and treatment strategies.

    • Main Results:

    • Significant increase in patient age and frequency of atherosclerotic heart disease in the later period.
    • Introduction of advanced cardiac procedures (catheterization, open-heart surgery) influenced clinical course.
    • Rheumatic heart disease persisted as the primary underlying condition; Streptococcus viridans remained the most frequent pathogen.
    • No cases of infective endocarditis related to drug addiction were identified.

    Conclusions:

    • Infective endocarditis presentation and management have evolved due to demographic shifts and medical advancements.
    • Despite changes, rheumatic heart disease and Streptococcus viridans remain key features of infective endocarditis.
    • The absence of drug-related cases in this cohort warrants further investigation in the Israeli context.