Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypoxic radiosensitization by the antimicrobial methyl paraben.

G P Jacobs, N Sade

    International Journal of Radiation Oncology, Biology, Physics
    |August 1, 1984
    PubMed
    Summary

    Methyl paraben enhances Staphylococcus aureus sensitivity to gamma radiation under anoxic conditions. This antimicrobial preservative increases radiation response without exhibiting toxicity to the bacteria.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Did the 2014 Ebola outbreak in Liberia affect HIV testing, linkage to care and ART initiation?

    Public health action·2017
    Same author

    A review of the effects of gamma radiation on pharmaceutical materials.

    Journal of biomaterials applications·1995
    Same author

    Topical chemotherapy of cutaneous Leishmaniasis.

    Parasitology today (Personal ed.)·1988
    Same author

    A note on the effect of gamma-rays on cefamandole and oxacillin.

    International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes·1987
    Same author

    Radiosensitization by diamide analogs and arsenicals.

    International journal of radiation oncology, biology, physics·1986
    Same author

    Non-nitro radiation sensitizers.

    International journal of radiation biology and related studies in physics, chemistry, and medicine·1986

    Area of Science:

    • Microbiology
    • Radiation Biology
    • Biochemistry

    Background:

    • Antimicrobial preservatives are crucial in various applications.
    • Understanding microbial responses to radiation is vital for sterilization and safety.
    • Methyl paraben is a widely used antimicrobial agent.

    Purpose of the Study:

    • To investigate the effect of methyl paraben on the radiosensitivity of Staphylococcus aureus.
    • To determine if methyl paraben can sensitize bacteria to gamma radiation under anoxic conditions.

    Main Methods:

    • Anoxic buffered suspensions of Staphylococcus aureus were prepared.
    • These suspensions were exposed to gamma radiation in the presence of varying concentrations of methyl paraben.
    • Bacterial survival or response was measured to assess radiosensitization.

    Main Results:

    • Methyl paraben significantly sensitized anoxic Staphylococcus aureus suspensions of Staphylococcus aureus to gamma radiation.
    • A maximal response was observed at 0.5 mM methyl paraben, showing a 150% increase in response compared to controls without the additive.
    • The observed sensitization approached 80% of the response seen in aerated suspensions.

    Conclusions:

    • Methyl paraben acts as a radiosensitizer for Staphylococcus aureus under anoxic conditions.
    • The preservative is effective in enhancing radiation's antimicrobial effect without being toxic itself.
    • These findings have implications for radiation-based sterilization and microbial control strategies.

    Related Experiment Videos