Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypoxic pulmonary vasoconstriction during steady and pulsatile flow in ferrets.

T J Gregory, M L Ellsworth, J C Newell

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |July 1, 1984
    PubMed
    Summary

    Hypoxia increases pulmonary arterial pressure in ferret lungs, with pulsatile flow offering no advantage over steady flow. Combined hypoxia and high airway pressure have additive effects on perfusion pressure.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    NOSER: An Algorithm for Solving the Inverse Conductivity Problem.

    International journal of imaging systems and technology·2023
    Same author

    Role of erythrocyte-released ATP in the regulation of microvascular oxygen supply in skeletal muscle.

    Acta physiologica (Oxford, England)·2015
    Same author

    Estimating a regional ventilation-perfusion index.

    Physiological measurement·2015
    Same author

    Calderón's method on an elliptical domain.

    Physiological measurement·2013
    Same author

    Simvastatin and GGTI-2133, a geranylgeranyl transferase inhibitor, increase erythrocyte deformability but reduce low O(2) tension-induced ATP release.

    American journal of physiology. Heart and circulatory physiology·2013
    Same author

    The Rho kinase inhibitor Y-27632 increases erythrocyte deformability and low oxygen tension-induced ATP release.

    American journal of physiology. Heart and circulatory physiology·2011

    Area of Science:

    • Physiology
    • Pulmonary Circulation

    Background:

    • Pulmonary circulation is sensitive to oxygen levels and flow patterns.
    • Understanding pressure-flow dynamics is crucial for respiratory research.

    Purpose of the Study:

    • To investigate the impact of hypoxia and pulsatile flow on pulmonary pressure-flow relationships in isolated ferret lungs.
    • To compare the effects of steady versus pulsatile flow under hypoxic conditions.

    Main Methods:

    • Isolated perfused ferret lungs were subjected to steady and pulsatile blood flow.
    • Alveolar partial pressure of oxygen (PO2) was reduced to induce hypoxia.
    • Pulmonary arterial pressure and flow were measured to determine pressure-flow curves.
    • The effects of elevated airway pressure were also assessed.

    Related Experiment Videos

    Main Results:

    • Hypoxia significantly increased pulmonary arterial pressure in ferret lungs under both steady and pulsatile flow conditions.
    • Pulsatile perfusion did not reduce perfusion pressures compared to steady flow during hypoxia.
    • Elevated airway pressure during hypoxia further increased perfusion pressure, indicating additive effects.

    Conclusions:

    • In ferret lungs, pulsatile perfusion does not mitigate the hypoxic pressor response.
    • Hypoxia and high airway pressure exert additive effects on pulmonary perfusion pressure.
    • Ferret pulmonary vascular responses to hypoxia differ from those observed in canine models.