Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The dexamethasone suppression test in schizophrenia.

J Sawyer, J J Jeffries

    The Journal of Clinical Psychiatry
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Society, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, London, Ont. Sept. 15-18, 2011.

    Canadian journal of surgery. Journal canadien de chirurgie·2022
    Same author

    Predictors of Post-operative Pain and Opioid Consumption in Patients Undergoing Liver Surgery.

    World journal of surgery·2019
    Same author

    Dose-dense and less dose-intense total therapy 5 for gene expression profiling-defined high-risk multiple myeloma.

    Blood cancer journal·2016
    Same author

    Dose-dense and less dose-intense Total Therapy 5 for gene expression profiling-defined high-risk multiple myeloma.

    Blood cancer journal·2016
    Same author

    On working together.

    Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2016
    Same author

    Hematopoietic progenitor cell collection after autologous transplant for multiple myeloma: low platelet count predicts for poor collection and sole use of resulting graft enhances risk of myelodysplasia.

    Leukemia·2013

    This study found a high rate of depression and dexamethasone nonsuppression in schizophrenia patients, challenging diagnostic criteria. Clinicians did not solely rely on the dexamethasone suppression test (DST) for treatment decisions.

    Area of Science:

    • Psychiatry
    • Neuroendocrinology

    Background:

    • Schizophrenia diagnosis and its overlap with mood disorders remain complex.
    • The dexamethasone suppression test (DST) has been investigated for its utility in diagnosing depression and differentiating psychiatric conditions.

    Purpose of the Study:

    • To investigate the incidence of depressed mood and dexamethasone nonsuppression in inpatients diagnosed with schizophrenia.
    • To examine the clinical utility and diagnostic implications of the DST in this population.

    Main Methods:

    • Study included 20 inpatients meeting DSM-III criteria for schizophrenia.
    • Assessed for depressed mood, DSM-III melancholia, and performed the dexamethasone suppression test (DST).
    • Compared DST results to expected rates from literature and analyzed treatment decisions based on DST outcomes.

    Related Experiment Videos

    Main Results:

    • High incidence of depressed mood (70%) and DSM-III melancholia (30%) observed.
    • Dexamethasone nonsuppression rate was 35%, significantly higher than the expected 4% (p < .001).
    • Clinical judgment, not solely DST results, guided antidepressant pharmacotherapy.

    Conclusions:

    • Findings support a significant proportion of depressed individuals within the schizophrenia diagnosis.
    • The results challenge the DSM-III exclusion of major depression in schizophrenia and the RDC's biological basis for primary/secondary depression.
    • The study raises questions about the specificity of the DST in psychiatric diagnostics.