Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microbubble dynamics visualized in the intact capillary circulation.

S B Feinstein, P M Shah, R J Bing

    Journal of the American College of Cardiology
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Experimental in vitro infection of rat osteoblasts with measles virus stimulates osteogenic differentiation.

    Biochemical and biophysical research communications·2014
    Same author

    Consolidated bioprocessing strategy for ethanol production from Jerusalem artichoke tubers by Kluyveromyces marxianus under high gravity conditions.

    Journal of applied microbiology·2011
    Same author

    Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activation.

    The international journal of biochemistry & cell biology·2006
    Same author

    Toxocara canis infections in a pig model: immunological, haematological and blood biochemistry responses.

    Journal of helminthology·2006
    Same author

    1alpha,25(OH)2D3 induces capacitative calcium entry involving a TRPC3 protein in skeletal muscle and osteoblastic cells.

    Biological research·2005
    Same author

    Evidence that TRPC3 is a molecular component of the 1alpha,25(OH)2D3-activated capacitative calcium entry (CCE) in muscle and osteoblast cells.

    The Journal of steroid biochemistry and molecular biology·2004
    Same journal

    Aortic Valve Replacement in Women of Reproductive Age.

    Journal of the American College of Cardiology·2026
    Same journal

    Sudden Death in Cardio-Kidney-Metabolic Patients: Insights From FINE-HEART.

    Journal of the American College of Cardiology·2026
    Same journal

    Ultra-Thin Sirolimus-Eluting Versus Everolimus-Eluting Stents in Diabetic Multivessel Coronary Artery Disease Patients: The TUXEDO-2 Trial.

    Journal of the American College of Cardiology·2026
    Same journal

    Reframing Cardiometabolic Risk and Frailty Through Sarcopenic Obesity.

    Journal of the American College of Cardiology·2026
    Same journal

    Imaging-Derived Sarcopenic Obesity and Cardiovascular Outcomes: Insights Into Heart Failure Risk and Muscle Biology.

    Journal of the American College of Cardiology·2026
    Same journal

    The Measure of a Leader: Lessons in Leadership From Eugene Braunwald.

    Journal of the American College of Cardiology·2026
    See all related articles

    Standardized microbubbles for contrast echocardiography are crucial. Smaller, uniform microbubbles generated by sonication pass easily through capillaries, unlike larger ones that block blood flow.

    Area of Science:

    • Cardiovascular imaging
    • Biomedical engineering
    • Microbubble dynamics

    Background:

    • Contrast echocardiography requires standardized echo contrast agents for myocardial perfusion studies.
    • Microbubble generation methods include hand-agitation and ultrasonic microcavitation (sonication).
    • Ultrasonic microcavitation produces smaller, more uniform microbubbles in vitro.

    Purpose of the Study:

    • To investigate the in vivo behavior and fate of microbubbles in a cat mesentery preparation.
    • To assess the impact of microbubble size and uniformity on microvascular passage.
    • To compare the performance of sonicated microbubbles versus larger microbubbles in vivo.

    Main Methods:

    • Direct microscopic examination of a cat mesentery preparation.

    Related Experiment Videos

  • Generation of microbubbles using hand-agitation and ultrasonic microcavitation.
  • Observation of microbubble passage through capillary vasculature.

    • Main Results:

    • Smaller, uniform microbubbles (sonicated) passed rapidly through capillaries with red blood cells.
    • Larger microbubbles coalesced, interrupted blood flow, and subsequently collapsed or shrank.
    • Microbubble size critically influences unhindered passage through the capillary vasculature.

    Conclusions:

    • Ultrasonic microcavitation produces microbubbles suitable for in vivo microvascular studies.
    • Microbubble size is a key determinant for effective contrast agent delivery in microcirculation.
    • Optimized microbubble characteristics are essential for advancing contrast echocardiography.