[Acute toxicity test of garlic extract].

Area of Science:

• Toxicology
• Pharmacology
• Natural Product Chemistry

Context:

• Garlic (Allium sativum) is widely used for culinary and medicinal purposes.
• Understanding the safety profile of herbal extracts is crucial for therapeutic applications.
• Rodent models are standard for preclinical toxicity assessments.

Purpose:

• To determine the acute toxicity of garlic extract in rodents.
• To establish the median lethal dose (LD50) of garlic extract via different administration routes.
• To observe any adverse effects following acute exposure to garlic extract.

Summary:

• Acute toxicity tests were conducted on Wistar rats and ddY mice using garlic extract.
• Oral (P.O.), intraperitoneal (I.P.), and subcutaneous (S.C.) administration routes were evaluated.
• LD50 values exceeded 30 ml/kg for all tested routes in both male and female rodents. A high dose of 30 ml/kg I.P. resulted in mortality in 5/10 male rats and 1/10 female rats, with no specific signs observed in survivors.

Impact:

• The study indicates a low acute toxicity for garlic extract in the tested rodent models.
• Findings support the general safety of garlic extract when used appropriately.
• Provides essential data for further research into the pharmacological effects and safe dosage ranges of garlic preparations.