The exocrine pancreas of patients with WDHA syndrome. A light and electron microscopical study

The exocrine pancreas of two patients with WDHA syndrome was studied by light and electron microscopy and by morphometrical methods. Compared to the controls, centroacinar and ductular cells were increased in number and richer in organelles, and acinar cells were markedly degranulated with well-developed ergastoplasm and Golgi apparatus. These findings suggest enhanced secretion of bicarbonate and enzymes in patients with WDHA syndrome. These results are discussed in the light of the complex metabolic and endocrine conditions occurring in this syndrome.