The fluctuation of circulating immune complexes level in patients with malignancy

Serum levels of circulating immune complexes (CIC) in 13 patients with breast cancer, 12 patients with uterine cervix cancer, 4 patients with uterine corpus cancer, 11 patients with lung cancer and 15 healthy persons were estimated by means of the PEGIKEM test during one day at 6 a. m., 11 a. m. and 5 p. m. Maximal deviations from the highest daily levels were expressed in percentage of them. These deviations range on average between 18-26 percent and are not significantly different from those of healthy persons (29 percent). Fluctuation of CIC levels in various patients differs in an individual manner. There is not the same tendency of changes of CIC level within two consecutive days, either. To interpret right a single value of CIC level one must be aware of its possible fluctuation.