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Alloplastic implants for the correction of refractive errors.

P S Binder, E Y Zavala, J K Deg

    Ophthalmology
    |July 1, 1984
    PubMed
    Summary
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    Hydrophilic lenticles implanted in baboon corneas show potential for correcting aphakia. Medium and high water content lenses were well-tolerated, with reversible outcomes.

    Area of Science:

    • Ophthalmology
    • Biomaterials Science

    Background:

    • The correction of aphakia (absence of the eye's natural lens) remains a significant challenge in ophthalmology.
    • Intracorneal lens implantation offers a potential alternative to traditional methods.

    Purpose of the Study:

    • To evaluate the safety and efficacy of convex-shaped, hydrophilic lenticles for aphakia correction in a baboon model.
    • To assess the impact of varying water content and material types on corneal response and visual outcomes.

    Main Methods:

    • Implantation of hydrophilic lenticles with varying water content into microkeratome-dissected corneal pockets in baboons.
    • Evaluation of freshly trephined, cryolathed, and factory-lathed hydrogels over 15 months.
    • Assessment of clinical response, corneal curvature, morphologic features, and reversibility of the procedure.

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    Main Results:

    • Medium and high water content lenticles demonstrated good clinical results without adverse effects on the recipient cornea.
    • Thick or low water content materials led to extrusion or severe anterior segment inflammation.
    • Reimplantation of alloplastic materials confirmed the reversibility of the procedure.

    Conclusions:

    • Convex-shaped, hydrophilic lenticles with medium to high water content are a viable option for correcting aphakia.
    • Current surgical techniques support the use of these intracorneal implants.
    • Material selection, particularly water content, is critical for successful outcomes.