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Related Experiment Videos

Intermittent claudication: prevalence and risk factors.

W G Hughson, J I Mann, A Garrod

    British Medical Journal
    |May 27, 1978
    PubMed
    Summary

    Smoking and high blood pressure are key risk factors for intermittent claudication (IC), a common condition. Managing these factors may help prevent this disabling manifestation of atherosclerosis.

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    Area of Science:

    • Vascular Medicine
    • Epidemiology
    • Public Health

    Background:

    • Intermittent claudication (IC) is a disabling manifestation of atherosclerosis.
    • Understanding the risk factors for IC is crucial for developing preventive strategies.

    Purpose of the Study:

    • To identify and quantify the risk factors associated with the development of intermittent claudication (IC).
    • To assess the prevalence of IC in a specific age group and its association with various risk factors.

    Main Methods:

    • A case-control study was conducted involving 54 patients diagnosed with IC and 108 controls.
    • Data collected included smoking status, blood pressure, and concentrations of triglyceride, urate, fibrinogen, and cholesterol.

    Main Results:

    • Smoking was the most significant risk factor for IC.
    • Elevated systolic and diastolic blood pressures, triglyceride, urate, and fibrinogen levels were significantly higher in IC patients.
    • The risk of IC increased multiplicatively with the presence of multiple risk factors.
    • Cholesterol levels were not associated with an increased risk of IC.

    Conclusions:

    • Intermittent claudication (IC) is associated with several modifiable risk factors, including smoking and hypertension.
    • The findings suggest that IC, a common condition, may be largely preventable through risk factor management.
    • Targeting smoking cessation and blood pressure control could significantly reduce the incidence of IC.

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