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Related Experiment Videos

Vasoactive intestinal peptide in cerebrospinal fluid.

N S Sharpless, L J Thal, M J Perlow

    Peptides
    |March 1, 1984
    PubMed
    Summary

    Vasoactive intestinal peptide (VIP) levels in cerebrospinal fluid (CSF) vary with neurological conditions. VIP may play a role in vasospasm after subarachnoid hemorrhage.

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    Area of Science:

    • Neuroscience
    • Endocrinology

    Background:

    • Vasoactive intestinal peptide (VIP) is a neuropeptide with known vasodilatory properties.
    • Understanding VIP's role in the central nervous system is crucial for neurological research.

    Purpose of the Study:

    • To measure immunoreactive VIP in cerebrospinal fluid (CSF) across various neurological disorders.
    • To investigate potential circadian patterns and implications of VIP in neurological conditions.

    Main Methods:

    • Measurement of immunoreactive VIP in human CSF (lumbar and ventricular) and rhesus monkey cisternal fluid.
    • Chromatographic analysis (Sephadex G-25 superfine) to characterize VIP forms.
    • Continuous fluid collection from monkeys for circadian rhythm assessment.

    Main Results:

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    • VIP levels in ventricular CSF were highest in hydrocephalic children and lowest in multiple sclerosis or epilepsy patients.
    • VIP was undetectable in comatose patients post-head injury and low in patients with aneurysm surgery.
    • Circadian patterns of CSF VIP were observed in rhesus monkeys, with higher levels at night.

    Conclusions:

    • VIP levels in CSF differ significantly across neurological disorders.
    • Reduced VIP in certain conditions may relate to neuronal function or vascular changes.
    • Findings suggest VIP's potential involvement in vasospasm following subarachnoid hemorrhage.