Effect of composition on the neutralizing properties of antacid preparations

11 antacid mixtures made up to simulate the preparations available on the market were prepared. These mixtures contain aluminium hydroxide gel, calcium carbonate, magnesium hydroxide and magnesium trisilicate. The antacid properties of the mixtures obtained were characterized by total acid consuming capacity, rate of neutralization and duration of action. It was indicated that the composition of the mixtures influenced their neutralizing properties; an interaction between constituents of these preparations was noted.