[123-I-labeled fatty acids for myocardial functional diagnosis]

For 17-123I-heptadecanoic acid (IHA) and 15-(para-123I-phenyl)-pentadecanoic acid (IPPA) the biochemical and pharmacokinetic results show a physiological behaviour similar to the normally occurring fatty acids. For the nuclear medical application both 123I-fatty acids are very well suited; they are fast and efficiently accumulated in the myocardium and, keeping the patient at rest, they allow to record scintigrams of the myocardium with a quality which is obtained with thallium 201 only under stress conditions of the patient. By sequential registration of the scintigrams time activity curves can be generated reflecting the regional in-vivo turnover of fatty acids in the myocardium. Thus in a non-invasive way it is possible to obtain differential informations of the myocardial function in-vivo.