Disposition of suprofen in rats following intravenous injection

Distribution and excretion of DL-2-(4-(2-thienylcarbonyl)phenyl)propionic acid (suprofen) were evaluated in male and female rats following intravenous (i.v.) injection of labeled suprofen. The radiometric findings following i.v. administration of 2 mg/kg of 3H-suprofen to male and female rats showed similar patterns of blood level and excretion of the radioactivity. Elimination of 3H-suprofen from the blood was rapid; most of the radioactivity was excreted in the urine and a portion in the feces within 24 h after injection. After rats with biliary fistulas were given an i.v. dose of 2 mg/kg of 3H-suprofen, approximately half of the dose was excreted in the bile during 48 h. The only tissues with concentrations higher than that in the plasma were those involved in metabolism and excretion (liver and kidney); other tissue levels were all very low and there was no evidence of accumulation of drug-related material in any tissue.