Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Haemostatic studies in osteogenesis imperfecta.

S A Evensen, L Myhre, H Stormorken

    Scandinavian Journal of Haematology
    |August 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Sublingual Tacrolimus in Liver Transplantation: A Valid Option?

    Transplantation proceedings·2016
    Same author

    Effect of pyridoxine on some haemostatic parameters.

    Thrombosis research·2010
    Same author

    Inhibition of cell proliferation and induction of apoptosis by N(1),N(11)-diethylnorspermine-induced polyamine pool reduction.

    Biochemical Society transactions·2007
    Same author

    Role of ADP and thromboxanes in human thrombus formation in ex vivo models.

    Platelets·2006
    Same author

    Disrespectful thoughts on dimensions in the outer and inner world.

    Cellular and molecular life sciences : CMLS·2004
    Same author

    Skin biopsies for early diagnosis and prognosis of graft-versus-host disease in recipients of allogeneic stem cells from blood or bone marrow.

    Bone marrow transplantation·2004
    Same journal

    Role of iron in the proliferation of the established human tumor cell lines U-937 and K-562: effects of suramin and a lipophilic iron chelator (PIH).

    Scandinavian journal of haematology·1986
    Same journal

    The efficacy and toxicity of VAD in the treatment of myeloma and related disorders.

    Scandinavian journal of haematology·1986
    Same journal

    RES phagocytosis in children with homozygous beta-thalassemia in relation to blood transfusion.

    Scandinavian journal of haematology·1986
    Same journal

    Two allotypes of factor IX present in haemophilia B.

    Scandinavian journal of haematology·1986
    Same journal

    Radioimmunoassay of erythropoietin in chronic uraemia or anephric patients.

    Scandinavian journal of haematology·1986
    Same journal

    Prognostic significance of a morphometric study of lymph node biopsies in chronic lymphocytic leukaemia.

    Scandinavian journal of haematology·1986
    See all related articles

    Osteogenesis imperfecta (OI) patients frequently experience easy bruising due to haemostatic defects. Increased capillary fragility and platelet dysfunction are common, suggesting OI

    Area of Science:

    • Hematology
    • Genetics
    • Pediatrics

    Background:

    • Osteogenesis imperfecta (OI) is a group of genetic disorders characterized by bone fragility.
    • Easy bruising is a common clinical manifestation in OI patients.
    • Haemostatic abnormalities may contribute to the bleeding tendency in OI.

    Purpose of the Study:

    • To investigate the specific haemostatic defects in patients with Osteogenesis Imperfecta, tarda type.
    • To identify the most frequent bleeding abnormalities in this patient cohort.
    • To evaluate the utility of screening tests for haemostatic dysfunction in OI.

    Main Methods:

    • Studied haemostasis in 58 subjects diagnosed with Osteogenesis Imperfecta, tarda type.
    • Assessed various haemostatic parameters including capillary fragility, platelet retention, and coagulation factor levels (Factor VIII R:Ag).

    Related Experiment Videos

  • Evaluated platelet aggregation responses to collagen and ristocetin cofactor activity.

    • Main Results:

    • Two-thirds of OI patients reported easy bruising.
    • Frequent abnormalities included increased capillary fragility (35%) and decreased platelet retention (33%).
    • Reduced Factor VIII R:Ag was observed in 23% of subjects, with other defects being less common.

    Conclusions:

    • OI patients exhibit a range of vascular, platelet, and plasmatic haemostatic defects.
    • These findings highlight the heterogeneity of OI, despite a common clinical presentation of easy bruising.
    • The tourniquet test is identified as a valuable screening tool for detecting haemostatic defects in OI.