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Cell recognition during neuronal development.

C S Goodman, M J Bastiani, C Q Doe

    Science (New York, N.Y.)
    |September 21, 1984
    PubMed
    Summary
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    Insect embryos reveal how developing neurons recognize each other. Cell interactions guide the expression of recognition molecules, leading to specific nerve connections essential for neuronal development.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Molecular Biology

    Background:

    • Insect embryos offer a model system to study neuronal development due to their simple nervous systems.
    • The grasshopper embryo provides accessible cells, while Drosophila offers accessible genes for genetic studies.

    Purpose of the Study:

    • To investigate the cellular and molecular mechanisms of cell recognition during neuronal development.
    • To understand how specific affinities between neuronal growth cones and axonal surfaces lead to selective fasciculation patterns.

    Main Methods:

    • Utilizing the grasshopper embryo for accessible cell studies and Drosophila for genetic analysis.
    • Employing monoclonal antibodies to identify surface molecules in the Drosophila embryo.

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    Main Results:

    • Identified selective affinities between growth cones and axonal surfaces, resulting in stereotyped fasciculation patterns.
    • Observed differential expression of cell recognition molecules on embryonic neurons, correlating with predicted functions.
    • Monoclonal antibodies revealed specific surface molecules in Drosophila embryos.

    Conclusions:

    • Cell lineage and interactions are crucial for differential expression of cell recognition molecules early in development.
    • These molecules mediate selective fasciculation of axons.
    • Future research can isolate genes for these molecules and test their function using Drosophila genetics.