Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Control of neuronal gene expression.

J G Sutcliffe, R J Milner, J M Gottesfeld

    Science (New York, N.Y.)
    |September 21, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Analysis of canine myeloid-derived suppressor cells (MDSCs) utilizing fluorescence-activated cell sorting, RNA protection mediums to yield quality RNA for single-cell RNA sequencing.

    Veterinary immunology and immunopathology·2020
    Same author

    Characterization of myeloid-derived suppressor cells and cytokines GM-CSF, IL-10 and MCP-1 in dogs with malignant melanoma receiving a GD3-based immunotherapy.

    Veterinary immunology and immunopathology·2019
    Same author

    Difficult airway equipment: a survey of standards across metropolitan Perth.

    Anaesthesia and intensive care·2014
    Same author

    In vitro effects of Yunnan Baiyao on canine hemangiosarcoma cell lines.

    Veterinary and comparative oncology·2014
    Same author

    Frameless stereotactic radiosurgery for the treatment of primary intracranial tumours in dogs.

    Veterinary and comparative oncology·2013
    Same author

    Integrating an evidence-based intervention into clinical practice: 'transitional relationship model'.

    Journal of psychiatric and mental health nursing·2012

    Identifier sequences in rat brain genes are transcribed into BC1 and BC2 RNAs by RNA polymerase III in neurons. This process may regulate neuronal gene expression by making gene promoters accessible.

    Area of Science:

    • Neuroscience
    • Molecular Biology
    • Genetics

    Background:

    • Approximately 30,000 genes are specific to the rat brain.
    • Many of these neuronal-specific genes contain identifier sequences within their introns.

    Purpose of the Study:

    • To investigate the role of identifier sequences in neuronal gene regulation.
    • To understand how these sequences are transcribed and their potential impact on gene accessibility.

    Main Methods:

    • Analysis of gene expression in the rat brain.
    • Identification and characterization of identifier sequences and their transcribed RNAs.
    • Investigating the role of RNA polymerase III in transcribing these sequences.

    Main Results:

    Related Experiment Videos

  • Identifier sequences are transcribed by RNA polymerase III exclusively in neurons.
  • This transcription produces two specific RNA species, BC1 and BC2.
  • The transcriptional event may define chromatin regions and prepare neuronal genes for transcription.

    • Conclusions:

    • The transcription of identifier sequences by RNA polymerase III is a key event in neuronal gene regulation.
    • BC1 and BC2 RNAs may play a role in modulating the accessibility of neuronal gene promoters.
    • This mechanism potentially poises neuronal genes for transcription by RNA polymerase II.