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[Various indicators of hemostasis and fibrinolysis systems in obese patients on reducing-diet therapy]
In view of setting new criteria of a thrombogenic risk, hemostasis was examined in 96 obesity patients and 30 control subjects. An increase in the fibrinogen level, inhibition of fibrinolytic activity, particularly of XIIa-kallikrein-dependent fibrinolysis were disclosed. No changes in the total blood coagulation activity were recorded. The fasting diet given to the patients for 18-20 days entailed a 12-15 kg weight reduction, fibrinogen level normalization, and fibrinolysis activation. Investigation of antithrombin activity in obesity patients' blood did not reveal any alterations.
In view of setting new criteria of a thrombogenic risk, hemostasis was examined in 96 obesity patients and 30 control subjects. An increase in the fibrinogen level, inhibition of fibrinolytic activity, particularly of XIIa-kallikrein-dependent fibrinolysis were disclosed. No changes in the total blood coagulation activity were recorded. The fasting diet given to the patients for 18-20 days entailed a 12-15 kg weight reduction, fibrinogen level normalization, and fibrinolysis activation. Investigation of antithrombin activity in obesity patients' blood did not reveal any alterations.