[Blood fibronectin level in experimental burn shock]

The blood fibronectin concentration in rats was measured by the ELISA during burn shock. Fifteen minutes after burn the fibronectin level was found to drop by 30% of the initial level on the average. Deep hypofibronectinemis lasted up to 24 h after burn. At the same time the clinical and pathomorphological picture of the shock was fairly pronounced. The survived animals demonstrated a progressive normalization of the fibronectin level. The fibronectin level completely returned to normal by the outcome of the second day after burn and then progressed to reactive hyperfibronectinemia by 70-72 h. The data obtained point to the involvement of fibronectin into the pathogenesis of burn shock, which is likely to be connected with the mechanism of reticuloendothelial system dysfunction.