[Histologic studies of the effect of superoxide dismutase on an arthrosis model in rabbits]

The effect of the enzyme superoxide dismutase (SOD) on experimentally induced osteoarthritis was investigated. Immobilization of the right knee of rabbits over variable periods (1-4 weeks) was used as the model for the study. SOD was applied intraarticularly. Distinct histological changes were detected in the immobilized joints in contrast to the freely mobile joints. In the group of rabbits treated with SOD, erosions, necroses, and inflammatory symptoms were more frequent than in the placebo group. The changes found in animals after SOD application indicate the enzyme has an intensifying effect on osteoarthritis.