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Related Experiment Videos

Serial alterations in endothelial cell shape and pattern after intraocular surgery.

M Matsuda, T Suda, R Manabe

    American Journal of Ophthalmology
    |September 15, 1984
    PubMed
    Summary

    Corneal endothelial cells showed initial changes after cataract surgery and keratoplasty. Hexagonality decreased post-surgery but gradually recovered over time in both procedures.

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    Area of Science:

    • Ophthalmology
    • Corneal Science
    • Cellular Biology

    Background:

    • The corneal endothelium is crucial for maintaining corneal clarity.
    • Understanding endothelial cell changes after ocular surgery is vital for predicting visual outcomes.
    • Intracapsular cataract extraction (ICCE) and penetrating keratoplasty (PK) are common procedures affecting the cornea.

    Purpose of the Study:

    • To evaluate the serial changes in corneal endothelial cellular pattern and thickness following ICCE and PK.
    • To assess the recovery of endothelial hexagonality and corneal thickness over time.
    • To compare the endothelial cell response between ICCE and PK.

    Main Methods:

    • Serial examination of central cornea endothelial cellular pattern and thickness.

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  • Computer-assisted digitizer used for endothelial pattern analysis.
  • Frequency of hexagonal cells used as an index for hexagonality.

    • Main Results:

    • After ICCE, hexagonality decreased from 68% to 52% within four weeks, then recovered to 64% by 24 weeks. Corneal thickness increased initially then returned to baseline.
    • After PK, hexagonality decreased from 62% to 53% within six months, with thickness reducing to 0.53 mm. Hexagonality gradually increased to 62% over two years.
    • Both ICCE and PK showed an initial decrease in endothelial hexagonality and altered corneal thickness, with subsequent partial recovery.

    Conclusions:

    • Corneal endothelial cells undergo significant changes after both ICCE and PK.
    • A gradual recovery of endothelial hexagonality is observed in the long term following these procedures.
    • Endothelial cell pattern and corneal thickness dynamics provide insights into corneal healing post-surgery.