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Pulmonary function changes in goats given 3-methylindole orally.

J E Mesina, G E Bisgard, G M Robinson

    American Journal of Veterinary Research
    |August 1, 1984
    PubMed
    Summary
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    Oral administration of 3-methylindole (3MI) in goats caused significant lung dysfunction, including decreased compliance and hypoxemia. This study details the pulmonary effects of 3MI toxicity in an animal model.

    Area of Science:

    • Veterinary Medicine
    • Pulmonary Toxicology
    • Animal Physiology

    Background:

    • 3-methylindole (3MI) is a toxic metabolite associated with respiratory disease in ruminants.
    • Understanding the precise pulmonary effects of 3MI is crucial for diagnosing and managing intoxication.

    Purpose of the Study:

    • To investigate the effects of orally administered 3-methylindole (3MI) on lung mechanics, ventilatory function, and clinical signs in adult goats.
    • To characterize the pathological changes in the lungs following 3MI exposure.

    Main Methods:

    • Six adult goats received an oral dose of 0.2 g of 3MI/kg body weight.
    • Lung function parameters were measured at multiple time points post-administration.
    • Clinical signs, gross and microscopic lung pathology, and morphometric analysis were performed.

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    Main Results:

    • Significant decreases in dynamic lung compliance and tidal volume were observed.
    • Increased airway resistance, respiratory frequency, and dead space to tidal volume ratio occurred.
    • Hypoxemia and mild metabolic acidosis were noted, alongside observed lung damage.

    Conclusions:

    • Oral 3MI administration induces severe pulmonary dysfunction and pathology in goats.
    • The observed changes highlight 3MI as a potent lung toxicant with significant implications for animal health.