Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bilateral optic neuritis. A long-term follow-up.

P J Parkin, R Hierons, W I McDonald

    Brain : a Journal of Neurology
    |September 1, 1984
    PubMed
    Summary

    The long-term outcomes for adults and children with bilateral optic neuritis show a variable visual prognosis in adults and excellent outcomes in children. The risk of developing multiple sclerosis is low in childhood but higher in adults.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    OS expansion.

    British dental journal·2019
    Same author

    CTG-repeat expansions in the DMPK gene do not cause takotsubo syndrome.

    International journal of cardiology·2015
    Same author

    A prospective study of "undiagnosed" isolated myelopathy: II. Value of magnetic resonance imaging, evoked potentials and CSF analysis.

    European journal of neurology·2013
    Same author

    Outwith utopia.

    British dental journal·2012
    Same author

    Sir geoffrey jefferson.

    Journal of the Royal Society of Medicine·2010
    Same author

    Electrical convulsive therapy.

    Lancet (London, England)·2010

    Area of Science:

    • Ophthalmology
    • Neurology
    • Clinical Medicine

    Background:

    • Bilateral optic neuritis is an inflammatory condition affecting the optic nerves.
    • Previous studies by Hierons and Lyle (1959) and Meadows (1969) reported cases of bilateral optic neuritis.
    • The long-term prognosis and risk of developing multiple sclerosis were not fully established.

    Purpose of the Study:

    • To determine the long-term fate of adults and children diagnosed with bilateral optic neuritis.
    • To assess the visual prognosis and the incidence of multiple sclerosis in these patient groups.
    • To investigate potential differences in outcomes based on the onset of optic neuritis (simultaneous vs. sequential).

    Main Methods:

    • Retrospective follow-up study of patients initially reported in 1959 and 1969.
    • Information gathered from various sources for long-term follow-up.
    • Analysis of visual outcomes and development of clinically definite multiple sclerosis.

    Main Results:

    • Follow-up data obtained for 31 of 34 adults (up to 37 years) and 17 of 19 children (up to 32 years).
    • Visual prognosis was variable in adults but excellent in children.
    • None of the children developed multiple sclerosis; 2 of 11 adults with simultaneous onset and 8 of 20 with sequential onset developed multiple sclerosis.

    Conclusions:

    • The risk of developing multiple sclerosis after simultaneous bilateral optic neuritis in childhood is low.
    • The risk appears higher in adults, though many remain free of disseminated disease even after decades.
    • Bilateral optic neuritis is a diverse condition with varied etiology and prognosis.

    Related Experiment Videos