Postnatal variations of endo-beta-D-N-acetyl-glucosaminidase in the developing rat cerebellum

Some properties and the level of endo-beta-N-acetylglucosaminidase were studied during the postnatal development of the rat cerebellum. No isoenzymes were detected. The enzyme (essentially cytosolic) showed a peak of total and specific activity at the 24th postnatal day. The hypothesis was formulated that glycoprotein glycans could be degraded in two steps: one lysosomal, the other cytosolic.