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Related Experiment Videos

Tyrophagus putrescentiae: an allergenically important mite.

W F Green, A J Woolcock

    Clinical Allergy
    |March 1, 1978
    PubMed
    Summary
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    Tyrophagus putrescentiae mites are a common allergen, causing reactions as frequently as Dermatophagoides pteronyssinus in Australian asthmatics. These mites are also prevalent in New Guinea, indicating their global significance in allergic diseases.

    Area of Science:

    • Allergy and Immunology
    • Environmental Health
    • Medical Entomology

    Background:

    • Mites are significant indoor allergens, with Dermatophagoides pteronyssinus widely recognized.
    • The role of other mite species, such as Tyrophagus putrescentiae, in allergic diseases requires further investigation.

    Purpose of the Study:

    • To compare the allergenicity of Tyrophagus putrescentiae with Dermatophagoides pteronyssinus in Australian and New Guinean populations.
    • To assess the prevalence of T. putrescentiae in homes in Sydney and New Guinea.
    • To investigate the immunological responses to T. putrescentiae.

    Main Methods:

    • Skin prick testing was performed on asthmatic patients in Sydney and normal individuals in New Guinea.
    • Mite counts were conducted in houses in Sydney and New Guinea.

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  • Serum IgE and IgG levels specific to T. putrescentiae and D. pteronyssinus were measured.

    • Main Results:

    • Positive skin reactions to T. putrescentiae were as common as those to D. pteronyssinus in Sydney asthmatics.
    • T. putrescentiae elicited the most frequent positive skin reactions in the normal New Guinean population.
    • Cross-reactivity in IgG antibodies between T. putrescentiae and D. pteronyssinus antigens was observed.

    Conclusions:

    • Tyrophagus putrescentiae is a significant allergen, comparable to D. pteronyssinus, and should be considered in allergy management.
    • The study highlights the importance of T. putrescentiae as a common allergen in both Australian and New Guinean populations.
    • A practical method for culturing and isolating T. putrescentiae was developed, facilitating further research.