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Fatal maprotiline intoxication.

R A Curtis, N Giacona, D Burrows

    Drug Intelligence & Clinical Pharmacy
    |September 1, 1984
    PubMed
    Summary
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    Maprotiline overdose can cause fatal drug toxicity and torsade de pointes, a dangerous heart rhythm. Autopsy tissue and plasma levels confirmed maprotiline toxicity, highlighting its cardiovascular risks.

    Area of Science:

    • Pharmacology
    • Toxicology
    • Cardiology

    Background:

    • Tetracyclic antidepressants, like maprotiline, are used for depression.
    • Understanding the toxicity profile of these agents is crucial for clinical management.
    • Cardiovascular side effects are a known concern with antidepressant medications.

    Observation:

    • A fatal case of maprotiline (Ludiomil) overdose was documented.
    • Autopsy revealed significant tissue and plasma concentrations of maprotiline.
    • The patient experienced torsade de pointes, a life-threatening cardiac arrhythmia.

    Findings:

    • Maprotiline overdose is associated with severe cardiotoxicity.
    • Torsade de pointes is a critical adverse event linked to maprotiline toxicity.

    Related Experiment Videos

  • Autopsy findings correlate drug levels with observed toxic effects.

    • Implications:

    • This case underscores the potential lethality of maprotiline overdose.
    • Clinicians should be vigilant for cardiac complications in maprotiline toxicity.
    • Further research into maprotiline's cardiovascular effects and pharmacokinetics is warranted.