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[Remarkable microbial findings in the small intestine mucosa of children]
Abstract:
In intestinal specimens of children repeatedly attacked by enteritis electron microscopic investigations were practiced. In 26% of biopsies mycosis was found and in 72% a bacterial infection of the intestinal mucosa. We found narrow contacts between the infectious agents and the mucosa by electron microscopic evaluation (adhesion, penetration, partly thick layers). The microbes found are suitable to maintain the recurring cases of diarrhoea. Our results demand an exact antibiotic and antimycotic therapy.
Insights
Microbial infections, including fungal (mycosis) and bacterial, were found in most children with recurrent enteritis. These infections adhered to and penetrated the intestinal lining, causing persistent diarrhea and necessitating precise antimicrobial and antifungal treatments.
Area of Science:
- Gastroenterology
- Microbiology
- Pediatrics
Context:
- Recurrent enteritis in children poses a significant health challenge.
- Electron microscopy is crucial for visualizing microbial interactions with the intestinal mucosa.
Purpose:
- To investigate the presence and nature of microbial infections in pediatric patients with recurrent enteritis.
- To evaluate the interaction between infectious agents and the intestinal lining using electron microscopy.
Summary:
- Electron microscopic examination of intestinal biopsies from children with recurrent enteritis revealed fungal infections (mycosis) in 26% and bacterial infections in 72% of cases.
- Microbes demonstrated close contact with the intestinal mucosa, including adhesion and penetration, forming thick layers in some instances.
- The identified microbes are capable of sustaining recurring episodes of diarrhea.
Impact:
- Findings underscore the role of microbial pathogens in persistent pediatric diarrhea.
- Results emphasize the need for accurate antibiotic and antimycotic therapies to manage recurrent enteritis effectively.
- This research highlights the importance of advanced imaging techniques in diagnosing complex gastrointestinal infections.