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Urinary polyamine excretion during the menstrual cycle.

S Osterberg, S Rosén, O Heby

    Clinical Chemistry
    |May 1, 1978
    PubMed
    Summary
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    Urinary polyamine levels, including putrescine, spermidine, and spermine, peak during menstruation and potentially ovulation in women. These findings highlight cyclical variations in polyamine excretion throughout the menstrual cycle.

    Area of Science:

    • Reproductive biology
    • Biochemistry
    • Urology

    Background:

    • Polyamines are essential for cell growth and proliferation.
    • Menstrual cycle involves significant physiological changes, including hormonal fluctuations and cellular turnover.
    • Understanding biochemical markers during the menstrual cycle is crucial for reproductive health research.

    Purpose of the Study:

    • To investigate the cyclical excretion patterns of urinary polyamines (putrescine, spermidine, spermine) throughout the menstrual cycle.
    • To determine if polyamine excretion correlates with specific phases of the menstrual cycle, such as menstruation and ovulation.

    Main Methods:

    • Collected daily urine samples from 13 healthy women over one complete menstrual cycle.
    • Utilized a fluorometric thin-layer chromatographic technique for precise measurement of urinary polyamines.

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  • Analyzed polyamine concentrations in relation to the menstrual cycle phases.

    • Main Results:

    • Urinary polyamine excretion showed considerable daily fluctuations.
    • Combined excretion of putrescine, spermidine, and spermine was highest during menstruation, often extending into the early follicular phase.
    • Many individuals exhibited enhanced polyamine excretion around the time of ovulation.

    Conclusions:

    • Urinary polyamine excretion exhibits a distinct cyclical pattern related to the menstrual cycle.
    • Menstruation is associated with the highest levels of urinary polyamines.
    • Ovulation may also be a period of increased polyamine excretion, warranting further investigation.