Effects of inhaled HF on lipid metabolism in guinea pigs

Guinea pigs were exposed to hydrogen fluoride (10 mg/m3) for 84 hr. Plasma triglyceride and cholesterol levels were significantly increased in the treated animals with respect to the controls. An increase in triglyceride levels was also observed in the liver. The metabolism of plasma and hepatic lipids was studied using incorporation of [1-14C]acetate. Compared to the control group, triglyceride synthesis was accelerated in the liver of the fluoride group. Extrahepatic lipoprotein lipase activity however was decreased in the fluoride group; this could be related to the decrease in apoprotein C.