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Hydralazine-induced cholangitis.

J L Myers, N A Augur

    Gastroenterology
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Hydralazine can cause acute cholangitis, a rare side effect. This case report details a patient who developed this condition after re-exposure to the drug, highlighting a previously undescribed adverse reaction.

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    Area of Science:

    • Pharmacology
    • Gastroenterology
    • Hepatology

    Background:

    • Hydralazine is a vasodilator used to treat hypertension.
    • Adverse drug reactions can manifest in various organ systems.
    • Acute cholangitis is typically associated with biliary obstruction or infection.

    Observation:

    • A 59-year-old woman experienced symptoms of acute cholangitis after inadvertently re-administering hydralazine.
    • Symptoms included fever, right upper quadrant tenderness, obtundation, and hypotension.
    • Surgical exploration revealed no evidence of biliary obstruction or infection.

    Findings:

    • Perioperative studies supported a diagnosis of hydralazine-induced acute cholangitis.
    • This represents a previously undescribed adverse effect of hydralazine.

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  • The patient's presentation mimicked idiopathic cholangitis but was linked to drug exposure.

    • Implications:

    • Clinicians should consider drug-induced cholangitis in patients presenting with acute cholangitis symptoms, especially with a history of hydralazine use.
    • This finding expands the known spectrum of hydralazine's adverse effects.
    • Further research may be warranted to elucidate the mechanism of hydralazine-induced cholangitis.