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Canine ceroid lipofuscinosis, a model for ageing of the human isocortex
Gerontology
|January 1, 1984
Abstract:
In canine ceroid lipofuscinosis (one case studied), isocortical layer IIIab pyramidal cells develop spindle-shaped enlargements of their proximal axon filled with lipopigment, a feature that can be observed in juvenile and adult type of human neuronal ceroid lipofuscinosis and in normal ageing of the human isocortex as well.