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Abstract:
The present increase in indications for application of calcium antagonists--beyond the area of coronary heart disease--is confirmed by pharmacological analyses. Due to calcium antagonists the contractility is decreased, which is followed by a decreased oxygen consumption in the heart and a relaxation of the vessels. Nowadays, the anti-arrhythmic and cardio-protective effects as well as the prevention of coronary spasms by these substances can be pharmacologically established.