A simple synthesis of 18F-labelled 5-fluorouracil using acetylhypofluorite

18F-labelled 5-fluorouracil was synthesized by reacting labelled acetylhypofluorite in situ with uracil. Evaporation in the presence of triethylamine yielded 18F-5-fluorouracil in an overall radiochemical yield of about 20-30%. The solution was purified by passing it through a Sep-Pak column.