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Related Experiment Videos

Transient cimetidine resistance.

W M Steinberg, J H Lewis, D M Katz

    Journal of Clinical Gastroenterology
    |August 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    A healthy woman experienced temporary resistance to cimetidine, a medication for gastric acid suppression. Her response varied despite consistent drug blood levels, suggesting potential stress-related mechanisms.

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    Area of Science:

    • Pharmacology
    • Gastroenterology

    Background:

    • Cimetidine is a histamine H2 receptor antagonist used to reduce gastric acid secretion.
    • Gastric intubation studies are employed to investigate drug effects on gastrointestinal physiology.

    Observation:

    • A healthy 27-year-old woman exhibited transient resistance to cimetidine during a 5-day study.
    • On specific days, cimetidine failed to suppress gastric acid despite achieving normal therapeutic blood concentrations.

    Findings:

    • The subject demonstrated variable intragastric pH response to cimetidine.
    • Peak cimetidine blood levels were comparable on days with and without gastric acid suppression.
    • This suggests a temporary, non-dose-dependent resistance to cimetidine's effects.

    Implications:

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    • The findings suggest potential non-pharmacokinetic factors influencing cimetidine efficacy.
    • A cholinergic response to stress is hypothesized as a possible cause for the observed resistance.
    • Further research is needed to elucidate mechanisms of transient drug resistance in vivo.