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Adrenal changes in genetically hypothyroid mice.

J G Shire, W G Beamer

    The Journal of Endocrinology
    |September 1, 1984
    PubMed
    Summary
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    The hypothyroid (hyt) mutation in mice poorly develops the adrenocortical X-zone. Thyroid powder treatment restored X-zone development, suggesting a link between thyroid hormones and adrenal function.

    Area of Science:

    • Endocrinology
    • Developmental Biology
    • Mouse Models

    Background:

    • The adrenocortical X-zone is a transient structure in the adrenal cortex of young mammals.
    • The function and regulation of the X-zone are not fully understood.
    • The hypothyroid (hyt) mutation in mice affects thyroid hormone production and response.

    Purpose of the Study:

    • To investigate the role of thyroid hormones in the development and regulation of the adrenocortical X-zone.
    • To examine the impact of the hypothyroid (hyt) mutation on X-zone morphology.
    • To explore the potential involvement of prolactin in mediating thyroid hormone effects on the adrenal cortex.

    Main Methods:

    • Utilized young female mice homozygous for the hypothyroid (hyt) mutation.
    • Administered thyroid powder to a subset of mutant mice.

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  • Observed and compared the development and morphology of the adrenocortical X-zone in treated and untreated mutant mice, as well as normal littermates.

    • Main Results:

    • Mice with the hypothyroid (hyt) mutation exhibited poor development of the adrenocortical X-zone.
    • Feeding thyroid powder to these mutant mice promoted the development of the X-zone.
    • The induced X-zone in treated mutants subsequently degenerated similarly to that in normal mice.

    Conclusions:

    • Thyroid hormone status significantly influences adrenocortical X-zone development in mice.
    • The hypothyroid (hyt) mutation's effect on the X-zone may be linked to altered prolactin stimulation due to impaired thyrotrophin response.
    • This study highlights a potential regulatory pathway involving thyroid hormones, prolactin, and adrenal cortex development.