Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evidence for cardiovascular autonomic nerve dysfunction in multiple sclerosis.

M P Senaratne, D Carroll, K G Warren

    Journal of Neurology, Neurosurgery, and Psychiatry
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Datopotamab deruxtecan versus chemotherapy in previously treated inoperable/metastatic hormone receptor-positive, HER2-negative breast cancer: final overall survival analysis of the phase III TROPION-Breast01 study.

    Annals of oncology : official journal of the European Society for Medical Oncology·2025
    Same author

    Mechanical circulatory support as a bridge to delivery in a pregnant patient with dilated cardiomyopathy and acute heart failure: a case report.

    International journal of obstetric anesthesia·2024
    Same author

    Evaluating a pilot mental health awareness for managers' training course.

    Occupational medicine (Oxford, England)·2019
    Same author

    Non-linear response of summertime marine productivity to increased meltwater discharge around Greenland.

    Nature communications·2018
    Same author

    Aquatic treadmill water level influence on pelvic limb kinematics in cranial cruciate ligament-deficient dogs with surgically stabilised stifles.

    The Journal of small animal practice·2017
    Same author

    Cardiovascular reactivity patterns and pathways to hypertension: a multivariate cluster analysis.

    Journal of human hypertension·2016

    Multiple sclerosis (MS) patients often exhibit cardiovascular autonomic dysfunction. This study found significant abnormalities in heart rate and blood pressure responses during breathing, Valsalva maneuvers, and exercise in MS patients compared to controls.

    Area of Science:

    • Neurology
    • Cardiovascular Physiology
    • Autonomic Nervous System Function

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease.
    • Autonomic nervous system dysfunction is a known complication of MS.
    • Cardiovascular autonomic function can be assessed through various physiological tests.

    Purpose of the Study:

    • To investigate cardiovascular autonomic function in patients with multiple sclerosis.
    • To compare autonomic responses in MS patients with those of healthy controls.
    • To identify specific deficits in autonomic control of heart rate and blood pressure in MS.

    Main Methods:

    • Autonomic function tests included heart rate variation during deep breathing.
    • Standardized Valsalva maneuver was performed to assess blood pressure and heart rate reflexes.

    Related Experiment Videos

  • Cardiovascular responses to graded arm ergometry were evaluated.

    • Main Results:

    • Patients with MS showed reduced heart rate variation during deep breathing compared to controls.
    • Four MS patients had abnormal Valsalva ratios, indicating impaired baroreflex sensitivity.
    • Heart rate and systolic blood pressure responses to exercise were significantly attenuated in several MS patients.

    Conclusions:

    • A significant proportion of multiple sclerosis patients exhibit evidence of cardiovascular autonomic dysfunction.
    • These findings highlight the impact of MS on the autonomic nervous system's control of the cardiovascular system.
    • Autonomic dysfunction in MS may contribute to various clinical symptoms and complications.