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Myocardial dysfunction in children with acute meningococcemia.

M M Boucek, R C Boerth, M Artman

    The Journal of Pediatrics
    |October 1, 1984
    PubMed
    Summary

    Acute meningococcemia can cause myocardial dysfunction, impacting cardiac output. Early detection and treatment of impaired heart function are crucial for survival in affected children.

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    Area of Science:

    • Pediatrics
    • Cardiology
    • Infectious Diseases

    Background:

    • Acute meningococcemia often leads to cardiovascular collapse of unknown origin.
    • Myocardial dysfunction is suspected in children with this condition.

    Purpose of the Study:

    • To prospectively assess myocardial function in children with acute meningococcemia.
    • To determine the relationship between myocardial function and clinical outcomes.

    Main Methods:

    • Clinical assessment and echocardiography were used to evaluate myocardial function.
    • Left ventricular shortening fraction (LVSF) was measured.
    • Cardiac output was assessed using thermodilution.

    Main Results:

    • 58% of children showed echocardiographic evidence of myocardial dysfunction (depressed LVSF).

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  • Depressed LVSF correlated with reduced cardiac output.
  • Myocardial dysfunction was associated with increased mortality and preceded cardiovascular collapse in some cases.

    • Conclusions:

    • Impaired myocardial function is common in acute meningococcemia and contributes to low cardiac output.
    • Assessing myocardial function (LVSF) is vital for guiding therapy and improving survival.
    • Therapeutic strategies should consider optimizing myocardial contractility alongside fluid resuscitation.