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[A child with successfully treated posterior mediastinal endodermal sinus tumor].

T Oka, F Inyaku, S Itoo

Gan No Rinsho. Japan Journal of Cancer Clinics

|August 1, 1984

Summary

A rare pediatric posterior mediastinal endodermal sinus tumor was successfully treated in a 15-month-old boy using surgery and VAC chemotherapy. This youngest patient shows no signs of recurrence 53 months post-operation.

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Area of Science:

Pediatric Oncology
Surgical Oncology
Medical Oncology

Background:

Endodermal sinus tumors (ESTs) are rare germ cell tumors, often presenting in the mediastinum.
Posterior mediastinal tumors can cause significant complications like hemothorax.
Early diagnosis and multimodal treatment are crucial for favorable outcomes in pediatric cancers.

Observation:

A 15-month-old boy presented with recurrent hemothorax due to a posterior mediastinal mass.
Elevated serum alpha-fetoprotein (AFP) levels were noted (29,520 ng/ml).
The patient underwent surgical tumor removal followed by chemotherapy.

Findings:

The patient received VAC (vincristine, actinomycin D, cyclophosphamide) chemotherapy for 18 months post-surgery.
Tumor markers (AFP) normalized after treatment.

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The patient remains disease-free with normal AFP levels 53 months post-operation and 35 months post-chemotherapy completion.

Implications:

This case highlights the successful management of a rare pediatric mediastinal endodermal sinus tumor.
It establishes a precedent for treating even the youngest patients with this condition.
Aggressive multimodal therapy, including surgery and chemotherapy, can lead to long-term remission in pediatric mediastinal ESTs.