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Updated: Aug 17, 2026
Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
[Functiono-morphological changes in the cardiovascular system in acute occlusion and after revascularization of the
Abstract:
A total of 56 experimental dogs with small intestine ischemia following the recovery of the blood flow were studied comprehensively for the cardio- and hemodynamic parameters as well as for myocardial contractility and bioelectric activity. Histologic, histochemical and histoenzymologic examination were carried out. Longer periods of ischemia were associated with the depletion of the cardiac functional reserve. The recovery of the blood flow following 6 to 12-hour long ischemia without corrective measures was accompanied by severe hypovolemia, marked dystrophic and metabolic changes in the myocardium as well as by diminished cardiac activity.
